CranEx

CranEx - 150:1 Premium Cranberry Extract that meets Authentic – Certified – Potency requirement of PharmaPrint

Most concentrated and the only sugar free cranberry extract on the market.

PharmaPrint CranEx is a clinically tested unique, full spectrum standardized phenolic extract produced from cranberry juice concentrate and is the highest phenolic extract concentration and biologic potency available from cranberry – it’s not just any run of the mill cranberry extract. Cranberry has been independently shown to maintain oral as well as bladder health and promote normal urine flow. 

The FDA has recently provided statements supportive of the daily use of 500 mg of cranberry dietary supplements for treatment and prevention of urinary tract infections (UTIs) in healthy females with a previous history. Daily use of 200mg of more concentrated CranEx taken twice daily showed excellent clinical benefits in females aged 25-70 years old with a history of chronic UTI's. 

CranEx is standardized to 30% total phenols extract and consists of the range of super fruit actives naturally found in juice and represents the most concentrated cranberry supplement available.

Potency is shown by 100 mg of extract equivalent to 20-40 oz. of cranberry juice with most of the sugars removed.

CranEx should be considered an essential daily requirement for the best approach to urinary tract health support.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place. Do not use if seal is broken.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients & Citations:

VITAMIN C

1). Peng D, Ge G, Gong Y, Zhan Y, He S, Guan B, Li Y, Xu Z, Hao H, He Z, Xiong G, Zhang C, Shi Y, Zhou Y, Ci W, Li X, Zhou L. Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer. Clin Epigenetics. 2018 Jul 13;10(1):94. doi: 10.1186/s13148-018-0527-7. PMID: 30005692; PMCID: PMC6045833.

CRANBERRY

2). Bailey DT, Dalton C, Joseph Daugherty F, Tempesta MS. Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study. Phytomedicine. 2007 Apr;14(4):237-41. doi: 10.1016/j.phymed.2007.01.004. Epub 2007 Feb 12. PMID: 17296290.

3). Blumberg JB, Camesano TA, Cassidy A, Kris-Etherton P, Howell A, Manach C, Ostertag LM, Sies H, Skulas-Ray A, Vita JA. Cranberries and their bioactive constituents in human health. Adv Nutr. 2013 Nov 6;4(6):618-32. doi: 10.3945/an.113.004473. PMID: 24228191; PMCID: PMC3823508.

4). Nowack R, Birck R. Cranberry products in the prevention of urinary tract infections: examining the evidence. Botanics: Targets and Therapy. 2015;5:45-54

https://doi.org/10.2147/BTAT.S62986

5). Jeitler M, Michalsen A, Schwiertz A, Kessler CS, Koppold-Liebscher D, Grasme J, Kandil FI, Steckhan N. Effects of a Supplement Containing a Cranberry Extract on Recurrent Urinary Tract Infections and Intestinal Microbiota: A Prospective, Uncontrolled Exploratory Study. J Integr Complement Med. 2022 May;28(5):399-406. doi: 10.1089/jicm.2021.0300. Epub 2022 Mar 14. PMID: 35285701; PMCID: PMC9127832.

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Vitamin C

Nam SM, Seo M, Seo JS, Rhim H, Nahm SS, Cho IH, Chang BJ, Kim HJ, Choi SH, Nah SY. Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function. Nutrients. 2019 Jan 15;11(1):176. doi: 10.3390/nu11010176. PMID: 30650605; PMCID: PMC6356429.

Nutrients 2019, 11(1), 176; https://doi.org/10.3390/nu11010176

Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD000980. doi: 10.1002/14651858.CD000980.pub4. PMID: 23440782; PMCID: PMC8078152

Cochrane Database Syst Rev. 2013 Jan; 2013(1): CD000980. 

Published online 2013 Jan 31. doi: 10.1002/14651858.CD000980.pub4

Nam SM, Seo M, Seo JS, Rhim H, Nahm SS, Cho IH, Chang BJ, Kim HJ, Choi SH, Nah SY. Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function. Nutrients. 2019 Jan 15;11(1):176. doi: 10.3390/nu11010176. PMID: 30650605; PMCID: PMC6356429.

Nutrients 2019, 11(1), 176; https://doi.org/10.3390/nu11010176

Vitamin C- provides healthy aging from the 2023 NIH-National Institute of Aging website recommendation

Vitamins and Minerals for Older Adults 

Cranberry:

Cranberries and Their Bioactive Constituents in Human Health. Adv. Nutr. 4: 618–632, 2013.

doi: 10.3945/an.113.004473   PMID: 24228191

Cranberry extract clinical study shows benefit in prevention of recurrent UTI's.

Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study. 2007 Apr;14(4):237-41.  

 DOI: 10.1016/j.phymed.2007.01.004

FDA Announces Qualified Health Claim for Cranberry Extract-based products and treating UTI's

https://www.fda.gov/food/cfsan-constituent-updates/fda-announces-qualified-health-claim-certain-cranberry-products-and-urinary-tract-infections 

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